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Effects of acute carotid baroreceptor stimulation on sympathetic nerve traffic in resistant and uncontrolled hypertension: a systematic review and meta-analysis

Hypertension Research (2024)Cite this article

Abstract

In resistant hypertensive patients acute carotid baroreflex stimulation is associated with a blood pressure (BP) reduction, believed to be mediated by a central sympathoinhbition.The evidence for this sympathomodulatory effect is limited, however. This meta-analysis is the first to examine the sympathomodulatory effects of acute carotid baroreflex stimulation in drug-resistant and uncontrolled hypertension, based on the results of microneurographic studies. The analysis included 3 studies assessing muscle sympathetic nerve activity (MSNA) and examining 41 resistant uncontrolled hypertensives. The evaluation included assessment of the relationships between MSNA and clinic heart rate and BP changes associated with the procedure. Carotid baroreflex stimulation induced an acute reduction in clinic systolic and diastolic BP which achieved statistical significance for the former variable only [systolic BP: −19.98 mmHg (90% CI, −30.52, −9.43), P < 0.002], [diastolic BP: −5.49 mmHg (90% CI, −11.38, 0.39), P = NS]. These BP changes were accompanied by a significant MSNA reduction [−4.28 bursts/min (90% CI, −8.62, 0.06), P < 0.07], and by a significant heart rate decrease [−3.65 beats/min (90% CI, −5.49, −1.81), P < 0.001]. No significant relationship was detected beween the MSNA, systolic and diastolic BP changes induced by the procedure, this being the case also for heart rate. Our data show that the acute BP lowering responses to carotid baroreflex stimulation, although associated with a significant MSNA reduction, are not quantitatively related to the sympathomoderating effects of the procedure. This may suggest that these BP effects depend only in part on central sympathoinhibition, at least in the acute phase following the intervention.

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Author notes

  1. These authors contributed equally: Annalisa Biffi, Fosca Quarti-Trevano

Authors and Affiliations

  1. Department of Statistics and Quantitative Methods, National Centre for Healthcare Research and Pharmacoepidemiology, University Milano-Bicocca, Milano, Italy

    Annalisa Biffi & Giovanni Corrao

  2. Clinica Medica, Department of Medicine and Surgery, University Milano-Bicocca, Milano, Italy

    Fosca Quarti-Trevano, Jennifer Vanoli, Raffaella Dell’Oro, Giuseppe Mancia & Guido Grassi

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  1. Annalisa Biffi
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  2. Fosca Quarti-Trevano
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  3. Jennifer Vanoli
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  4. Raffaella Dell’Oro
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  5. Giovanni Corrao
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  6. Giuseppe Mancia
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  7. Guido Grassi
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Correspondence to Guido Grassi.

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Biffi, A., Quarti-Trevano, F., Vanoli, J. et al. Effects of acute carotid baroreceptor stimulation on sympathetic nerve traffic in resistant and uncontrolled hypertension: a systematic review and meta-analysis. Hypertens Res (2024). https://doi.org/10.1038/s41440-024-01704-9

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