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A multicenter matched-cohort analysis of gastroschisis outcomes in infants born before 32 weeks gestation

Journal of Perinatology (2024)Cite this article

Subjects

Objective

To examine neonatal outcomes of infants with gastroschisis born <32 weeks’ gestation compared to matched infants without gastroschisis.

Study design

Retrospective matched-cohort analysis of infants with gastroschisis born <32 weeks’ gestation at Children’s Hospitals Neonatal Consortium (CHNC) NICUs from 2010 to 2022 compared to gestational age-matched controls.

Results

The study included 119 infants with gastroschisis and 357 matched infants; 60% of infants born 29–32 weeks, 23% born 26–28 weeks, and 16% born < 25 weeks. Mortality was not significantly different between groups (11% vs. 9%, p = 0.59). Preterm co-morbidities such as IVH, BPD, ROP, and PVL were similar, as were rates of surgical NEC. Infants with gastroschisis had longer hospital stays (92 vs. 67 days), higher CLABSI and UTIs, and were more likely to need feeding support at discharge.

Conclusion

Compared to infants without gastroschisis, infants <32 weeks’ gestation with gastroschisis had similar risks for inpatient mortality, NEC, and other preterm co-morbidities.

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Data availability

Data from the study are not available for sharing.

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Funding

Funding

This study was not funded.

Author information

Authors and Affiliations

  1. University of Arkansas for Medical Sciences, Little Rock, AR, USA

    C. Preston Pugh & Franscesca Miquel-Verges

  2. Children’s Hospitals Neonatal Consortium, Dover, DE, USA

    Isabella Zaniletti

  3. Medical College of Wisconsin, Milwaukee, WI, USA

    T. Hang Nghiem-Rao & Krishna Acharya

  4. Wake Forest University School of Medicine, Winston-Salem, NC, USA

    L. Corbin Downey

  5. UAB Heersink School of Medicine and Children’s of Alabama, Birmingham, AL, USA

    Hannah Hightower

  6. University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora, CO, USA

    Theresa Grover

  7. Feinberg School of Medicine, Northwestern University; Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA

    Karna Murthy

  8. Cincinnati Children’s Hospital and University of Cincinnati Department of Pediatrics, Cincinnati, OH, USA

    Stefanie Riddle

Authors
  1. C. Preston Pugh
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  2. Isabella Zaniletti
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  4. T. Hang Nghiem-Rao
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  6. Hannah Hightower
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  7. Theresa Grover
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  8. Karna Murthy
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  9. Stefanie Riddle
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  10. Krishna Acharya
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Consortia

the Children’s Hospitals Neonatal Consortium Gastroschisis Focus Group

  • C. Preston Pugh
  • , Isabella Zaniletti
  • , Franscesca Miquel-Verges
  • , T. Hang Nghiem-Rao
  • , L. Corbin Downey
  • , Hannah Hightower
  • , Theresa Grover
  • , Karna Murthy
  • , Stefanie Riddle
  •  & Krishna Acharya

Contributions

All authors contributed to the study design, investigation, and preparation of the manuscript.

Corresponding author

Correspondence to Krishna Acharya.

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Competing interests

The authors declare no competing interests.

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Pugh, C.P., Zaniletti, I., Miquel-Verges, F. et al. A multicenter matched-cohort analysis of gastroschisis outcomes in infants born before 32 weeks gestation. J Perinatol (2024). https://doi.org/10.1038/s41372-024-01974-8

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  • DOI: https://doi.org/10.1038/s41372-024-01974-8

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