Measuring the kinetics of nucleotide incorporation during single-molecule, real-time DNA sequencing allows identification of methylated bases during the sequencing process.
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References
Jones, P.A. & Baylin, S.B. Nat. Rev. Genet. 3, 415–428 (2002).
Laird, P.W. Nat. Rev. Genet. 11, 191–203 (2010).
Flusberg, B.A. et al. Nat. Methods 7, 461–465 (2010).
Frommer, M. et al. Proc. Natl. Acad. Sci. USA 89, 1827–1831 (1992).
Cokus, S.J. et al. Nature 452, 215–219 (2008).
Lister, R. et al. Cell 133, 523–536 (2008).
Zemach, A. et al. Science published online, doi: 10.1126/science.1186366 (15 April 2010).
Feng, S. et al. Proc. Natl. Acad. Sci. USA published online, doi: 10.1073/pnas.1002720107 (15 April 2010).
Lister, R. et al. Nature 462, 315–322 (2009).
Laurent, L. et al. Genome Res. 20, 320–331 (2010).
Tahiliani, M. et al. Science 324, 930–935 (2009).
Kriaucionis, S. & Heintz, N. Science 324, 929–930 (2009).
Clarke, J. et al. Nat. Nanotechnol. 4, 265–270 (2009).
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Ecker, J. Zeroing in on DNA methylomes with no BS. Nat Methods 7, 435–437 (2010). https://doi.org/10.1038/nmeth0610-435
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DOI: https://doi.org/10.1038/nmeth0610-435