Rauscher, B. et al. Nucleic Acids Res. http://dx.doi.org/10.1093/nar/gkw997 (2016).

CRISPR–Cas9-based genome-wide screens have accumulated a large body of data that shed light on genotype–phenotype relationships. To facilitate access to this information, Rauscher et al. present a database that hosts more than half a million data points from over 80 high-throughput perturbation experiments that induced null mutations or used transcriptional activation or repression in human cells. GenomeCRISPR (http://genomecrispr.org) can be mined for single genes or for genomic regions, it can be used to rank single guide RNAs based on their effect, and it facilitates comparative analyses in multiple cell lines using phenotypic and genome tracks. The authors plan to expand the database as more data become available and include organisms other than human for cross-species comparison.