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The fate of cell reprogramming

Nature Methods volume 11, pages 1006–1008 (2014)Cite this article

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The ability to convert somatic cells to induced pluripotent stem cells has immense potential to further our understanding of development and disease mechanisms, and for cellular therapy. Before researchers can achieve these goals, they must expand current methodology to incorporate animal models and quantitative descriptions of the essential phenomena driving reprogramming.

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Figure 1: A cell in the pluripotent state can be thought to sit at the top of a hill from which signals pull it down into its differentiated state.

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Acknowledgements

We thank Y. Miyake for all her administrative support.

Author information

Author notes

  1. Shinya Yamanaka is at the Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA.

Authors and Affiliations

  1. Peter Karagiannis and Shinya Yamanaka are at the Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.,

    Peter Karagiannis & Shinya Yamanaka

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  1. Peter Karagiannis
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  2. Shinya Yamanaka
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Corresponding author

Correspondence to Shinya Yamanaka.

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Competing interests

S.Y. is a member without salary of the scientific advisory board of iPS Academia Japan.

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Karagiannis, P., Yamanaka, S. The fate of cell reprogramming. Nat Methods 11, 1006–1008 (2014). https://doi.org/10.1038/nmeth.3109

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