Figiel, M. et al. Mol. Neurobiol. 46, 393–429 (2012).

Switonski, P.M. et al. Mol. Neurobiol. 46, 430–466 (2012).

The polyglutamine (poly(Q)) family of neurological disorders—which includes Huntington's disease, spinal muscular atrophy and spinocerebellar ataxias, among others—is characterized by the expansion of CAG repeats in the coding region of causative genes. To date, more than 100 poly(Q) mouse models have been created, which makes it difficult to find, compare and translate the information between them. To aggregate information about this valuable resource, Figiel et al. and Switonski et al. collected and analyzed the body of data related to behavioral, molecular, cellular and anatomical characteristics of poly(Q) mouse models (Figiel et al., 2012) as well as the in vivo experimental therapeutic approaches used to treat them (Switonski et al., 2012). The data have been compiled in two review articles and corresponding Excel tables for easy navigation.