Unraveling the intracellular networks that regulate the self-renewal and differentiation of hematopoietic stem cells (HSCs) is crucial to enhancing the efficacy of these therapeutic transplantable cells. A newly discovered pathway links a leukemia tumor suppressor gene with a nutrient sensor to regulate fatty-acid oxidation (FAO) and stem cell division—information with the potential for modulating hematopoiesis for clinical advantage (pages 1350–1358).
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Broxmeyer, H., Mantel, C. A ROSy future for metabolic regulation of HSC division. Nat Med 18, 1334–1336 (2012). https://doi.org/10.1038/nm.2917
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DOI: https://doi.org/10.1038/nm.2917
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