The elementary molecular structure responsible for initiating T cell receptor signaling is unknown. Distinct microclusters of a few tens of molecules may accomplish this.
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Katie Ris
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Trautmann, A. Microclusters initiate and sustain T cell signaling. Nat Immunol 6, 1213–1214 (2005). https://doi.org/10.1038/ni1205-1213
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DOI: https://doi.org/10.1038/ni1205-1213
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