Regulatory T cells that express the transcription factor Foxp3 are pivotal in suppressing autoimmune responses. A report in this issue describes a key role for interleukin 10 produced by lamina propria macrophages in maintaining Foxp3 expression during inflammatory responses in the intestine.
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Unutmaz, D., Pulendran, B. The gut feeling of Treg cells: IL-10 is the silver lining during colitis. Nat Immunol 10, 1141–1143 (2009). https://doi.org/10.1038/ni1109-1141
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DOI: https://doi.org/10.1038/ni1109-1141
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