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Accessory to inflammation

Nature Immunology volume 11, pages 883–885 (2010)Cite this article

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IL-1 signaling requires a heterotrimeric complex of IL-1 receptor, its homolog IL-1RAcP and ligand. The crystal structure of this complex has now been solved, with implications for signaling by many IL-1 family members.

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Figure 1: Top, formation of the IL-1R complex, with the ligand IL-1β first binding to IL-1R, followed by recruitment of IL-1RAcP to the IL-1β–IL-1R complex.

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  1. John E. Sims is with Inflammation Research, Amgen, Seattle, Washington, USA.,

    John E Sims

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  1. John E Sims
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Correspondence to John E Sims.

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J.S. is an employee of and owns stock and stock options in Amgen.

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Sims, J. Accessory to inflammation. Nat Immunol 11, 883–885 (2010). https://doi.org/10.1038/ni1010-883

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