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Incompatible differences: view of an allogeneic pMHC-TCR complex

How do T cells recognize allogeneic MHC molecules with such ferocity? The first crystal structure of an allo-MHC complexed with peptide and T cell receptor begins to reveal the answer.

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Figure 1: A large fraction of peripheral T cells in an individual can react with an allo-MHC molecule

References

  1. Resier, J.-B. et al. Nature Immunol. 1, 291– 297 (2000).

    Article  Google Scholar 

  2. Bevan, M. J. Immunol. Today 5, 128–130 (1984).

    Article  CAS  Google Scholar 

  3. Sherman, L. A. & Chattopadhyay, S. Annu. Rev. Immunol. 11, 385–402 (1993).

    Article  CAS  Google Scholar 

  4. Udaka, K., Tsomides, T. J., Walden, P. P., Fukusen, N. & Eisen, H. N. Proc. Natl Acad. Sci. USA 90, 11272–11276 (1993).

    Article  CAS  Google Scholar 

  5. Davis, M. M. et al. Annu. Rev. Immunol. 16, 523– 544 (1998).

    Article  CAS  Google Scholar 

  6. Manning, T. C. & Kranz, D. M. Immunol. Today 20, 417–422 (1999).

    Article  CAS  Google Scholar 

  7. Sykulev, Y. et al. Proc. Natl Acad. Sci. USA 91, 11487 –11491 (1994).

    Article  CAS  Google Scholar 

  8. Obst, R., Netuschil, N., Klopfer, K., Stevanovic, S. & Rammensee, H. G. J. Exp. Med. 191 , 805–812 (2000).

    Article  CAS  Google Scholar 

  9. Daniel, C., Horvath, S. & Allen, P. M. Immunity 8, 543– 552 (1998).

    Article  CAS  Google Scholar 

  10. Manning, T. C. et al. Immunity 8, 413–425 (1998).

    Article  CAS  Google Scholar 

  11. Lee, P. U., Churchill, H. R., Daniels, M., Jameson, S. C. & Kranz, D. M. J. Exp. Med. 191, 1355–1364 (2000).

    Article  CAS  Google Scholar 

  12. Garcia, K. C. et al. Science 279, 1166– 1172 (1998).

    Article  CAS  Google Scholar 

  13. Speir, J. A. et al. Immunity 8, 553–562 (1998).

    Article  CAS  Google Scholar 

Download references

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Kranz, D. Incompatible differences: view of an allogeneic pMHC-TCR complex. Nat Immunol 1, 277–278 (2000). https://doi.org/10.1038/79716

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