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'TaiLoRing' the response of dendritic cells to pathogens

Cells of the innate and adaptive immune systems often require signals emanating from diverse cell surface receptors for full activation. For dendritic cells, synergistic stimulation by different pairs of Toll-like receptors provides the host with a mechanism to react rapidly and specifically to different pathogens.

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Figure 1: Cooperativity between the signaling pathways operated by TLR3 and TLR7, TLR8 and TLR9.

Katie Ris

References

  1. Millet, A.C. & Ewbank, J.J. Curr. Opin. Immunol. 16, 4–9 (2004).

    Article  CAS  Google Scholar 

  2. Vivier, E. & Malissen, B. Nat. Immunol. 6, 17–21 (2005).

    Article  CAS  Google Scholar 

  3. Takeda, K. & Akira, S. Int. Immunol. 17, 1–14 (2005).

    Article  CAS  Google Scholar 

  4. Napolitani, G., Rinaldi, A., Bertoni, F., Sallusto, F. & Lanzavecchia, A. Nat. Immunol. 6, 769–776 (2005).

    Article  CAS  Google Scholar 

  5. Takaoka, A. et al. Nature 434, 243–249 (2005).

    Article  CAS  Google Scholar 

  6. Honda, K. et al. Nature 434, 772–777 (2005).

    Article  CAS  Google Scholar 

  7. Gautier, G. et al. J. Exp. Med. 201, 1435–1446 (2005).

    Article  CAS  Google Scholar 

  8. Rogers, N.C. et al. Immunity 22, 507–517 (2005).

    Article  CAS  Google Scholar 

  9. Partida-Sanchez, S. et al. Immunity 20, 279–291 (2004).

    Article  CAS  Google Scholar 

  10. Hamerman, J.A., Tchao, N.K., Lowell, C.A. & Lanier, L.L. Nat. Immunol. 6, 579–586 (2005).

    Article  CAS  Google Scholar 

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Malissen, B., Ewbank, J. 'TaiLoRing' the response of dendritic cells to pathogens. Nat Immunol 6, 749–750 (2005). https://doi.org/10.1038/ni0805-749

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