Hematopoietic lineage schemes commonly show two distinct lymphoid and myeloid branches arising from the hematopoietic stem cell early during blood cell development. A new study of human hematopoiesis demonstrates that, similar to findings in mice, this split is not as dichotomous as is often presented.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Doulatov, S. et al. Nat. Immunol. 11, 585–593 (2010).
Abramson, S., Miller, R.G. & Phillips, R.A. J. Exp. Med. 145, 1567–1579 (1977).
Keller, G., Paige, C., Gilboa, E. & Wagner, E.F. Nature 318, 149–154 (1985).
Dick, J.E., Magli, M.C., Huszar, D., Phillips, R.A. & Bernstein, A. Cell 42, 71–79 (1985).
Fialkow, P.J., Denman, M.D., Jacobson, R.J. & Lowenthal, M.N. J. Clin. Invest. 62, 815–823 (1978).
Kondo, M. et al. Annu. Rev. Immunol. 21, 759–806 (2003).
Blom, B. & Spits, H. Annu. Rev. Immunol. 24, 287–320 (2006).
Katsura, Y. Nat. Rev. Immunol. 2, 127–132 (2002).
Adolfsson, J. et al. Cell 121, 295–306 (2005).
Baba, Y., Pelayo, R. & Kincade, P.W. Trends Immunol. 25, 645–649 (2004).
Payne, K.J. & Crooks, G.M. Immunity 26, 674–677 (2007).
Shizuru, J.A., Negrin, R.S. & Weissman, I. Annu. Rev. Med. 56, 509–538 (2005).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Dorshkind, K. Not a split decision for human hematopoiesis. Nat Immunol 11, 569–570 (2010). https://doi.org/10.1038/ni0710-569
Issue Date:
DOI: https://doi.org/10.1038/ni0710-569