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LRRK2 and Nod2 promote lysozyme sorting in Paneth cells

Nature Immunology volume 16, pages 898–900 (2015)Cite this article

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Paneth cell dysfunction has been linked to Crohn's disease. Nod2 and LRRK2, two genetic susceptibility factors for this disease, are now shown to have a role in regulating the sorting of lysozyme in Paneth cells and its secretion into the crypt space and, ultimately, in maintenance of the intestinal barrier.

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Figure 1: Nod2, LRRK2 and Rab2a promote cargo sorting of lysozyme to DCVs in Paneth cells to maintain host-microbiota homeostasis.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Juliana D.B. Rocha and Dana J. Philpott are in the Department of Immunology, University of Toronto, Toronto, Canada.,

    Juliana D B Rocha & Dana J Philpott

  2. Michael G. Schlossmacher is in the Division of Neuroscience and the Division of Neurology, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.,

    Michael G Schlossmacher

Authors
  1. Juliana D B Rocha
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  2. Michael G Schlossmacher
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  3. Dana J Philpott
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Correspondence to Dana J Philpott.

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Rocha, J., Schlossmacher, M. & Philpott, D. LRRK2 and Nod2 promote lysozyme sorting in Paneth cells. Nat Immunol 16, 898–900 (2015). https://doi.org/10.1038/ni.3255

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