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Co-ordination of intrathymic self-representation

Nature Immunology volume 16, pages 895–896 (2015)Cite this article

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Intrathymic expression of self antigens is key for central tolerance. RNA-sequencing analysis of tissue-restricted antigens in individual medullary thymic epithelial cells reveals co-ordination in the gene-expression patterns that ensures effective self-representation for the production of self-tolerant T cells.

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Figure 1: Co-ordinated patterns of self-representation in mTECs.

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Authors and Affiliations

  1. Graham Anderson and William E. Jenkinson are with the MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, UK.,

    Graham Anderson & William E Jenkinson

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  1. Graham Anderson
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  2. William E Jenkinson
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Correspondence to Graham Anderson.

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Anderson, G., Jenkinson, W. Co-ordination of intrathymic self-representation. Nat Immunol 16, 895–896 (2015). https://doi.org/10.1038/ni.3251

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