Virus-triggered type I interferon induces the lysine methyltransferase Setdb2; this then generates repressive histone marks on the promoters of genes encoding molecules important for antibacterial immunity. This process can contribute to influenza virus–associated bacterial superinfection.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Schliehe C. et al. Nat. Immunol. 16, 67–74 (2015).
Cruveilhier, L. Ann. Inst. Pasteur 33, 448–461 (1919)
Trinchieri, G. J. Exp. Med. 207, 2053–2063 (2010).
Morens, D.M. et al. J. Infect. Dis. 198, 962–970 (2008).
Shrestha, S. et al. Sci. Transl. Med. 5, 191ra184 (2013).
McCullers, J.A. Nat. Rev. Microbiol. 12, 252–262 (2014).
Kudva, A. et al. J. Immunol. 186, 1666–1674 (2011).
Li, W. et al. J. Virol. 86, 12304–12312 (2012).
Navarini, A.A. et al. Proc. Natl. Acad. Sci. USA 103, 15535–15539 (2006).
Nakamura, S. et al. J. Clin. Invest. 121, 3657–3665 (2011).
Shahangian, A. et al. J. Clin. Invest. 119, 1910–1920 (2009).
Goulding, J. et al. Proc. Am. Thorac. Soc. 4, 618–625 (2007).
Crotta, S. et al. PLoS Pathog. 9, e1003773 (2013).
Sun, K. & Metzger, D.W. Nat. Med. 14, 558–564 (2008).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Wack, A. Stop the executioners. Nat Immunol 16, 6–8 (2015). https://doi.org/10.1038/ni.3055
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.3055