Chitinase-like proteins are associated with type 2 immune responses and the 'wound-healing' pathway, but their role has remained unclear. Studies have now highlighted their contribution to IL-17 production and their link to neutrophil activity required for the control of helminth infection.
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Muallem, G., Hunter, C. ParadYm shift: Ym1 and Ym2 as innate immunological regulators of IL-17. Nat Immunol 15, 1099–1100 (2014). https://doi.org/10.1038/ni.3032
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DOI: https://doi.org/10.1038/ni.3032
