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Loss of translation: a stealth weapon against pathogens?

Nature Immunology volume 14, pages 1203–1205 (2013)Cite this article

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Various receptors alert cells to microbial invasion through the detection of conserved molecular patterns and initiate innate immunity. During infection with Legionella pneumophila, macrophages modulate cytokine responses by downregulating protein synthesis according to the pathogenic potential of the intruder.

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Figure 1: Breaching of the endosome by pathogenic Legionella promotes inflammation.

Debbie Maizels

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Authors and Affiliations

  1. Centre d'Immunologie de Marseille-Luminy, Aix-Marseille Université, UM2, Marseille, France

    Philippe Pierre & Evelina Gatti

  2. INSERM, Marseille, U1104, France

    Philippe Pierre & Evelina Gatti

  3. CNRS, UMR, Marseille, 7280, France

    Philippe Pierre & Evelina Gatti

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  1. Philippe Pierre
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  2. Evelina Gatti
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Correspondence to Philippe Pierre or Evelina Gatti.

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Pierre, P., Gatti, E. Loss of translation: a stealth weapon against pathogens?. Nat Immunol 14, 1203–1205 (2013). https://doi.org/10.1038/ni.2759

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