A fundamental mystery of the biology of germinal center B cells is why it seems that these rapidly dividing B cells lack expression of c-Myc, a transcriptional regulator intimately linked to cell metabolism and proliferation. This mystery has now been resolved.
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Debbie Maizels
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Shaffer, A., Staudt, L. The case of the missing c-Myc. Nat Immunol 13, 1029–1031 (2012). https://doi.org/10.1038/ni.2455
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DOI: https://doi.org/10.1038/ni.2455
