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It takes two to tango: a new couple in the family of ubiquitin-editing complexes

Nature Immunology volume 12, pages 1133–1135 (2011)Cite this article

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Improper termination of inflammatory signals can contribute to tumorigenesis. Cyld and Itch form an ubiquitin-editing complex that cooperatively downregulates the kinase Tak1 and thereby attenuates downstream activation of the transcription factor NF-κB.

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Figure 1: The growing family of ubiquitin-editing enzyme complexes.

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  1. Ingrid E. Wertz is in the Department of Early Discovery Biochemistry, Genentech, South San Francisco, California, USA.,

    Ingrid E Wertz

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  1. Ingrid E Wertz
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Correspondence to Ingrid E Wertz.

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I.E.W. is an employee of Genentech Inc., a for-profit institution.

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Wertz, I. It takes two to tango: a new couple in the family of ubiquitin-editing complexes. Nat Immunol 12, 1133–1135 (2011). https://doi.org/10.1038/ni.2165

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