Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

TL we meet again

The MHC class I–like molecule TL selects high-affinity effector memory T cells to man the barriers in the intestinal mucosa.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A model of TL-mediated selection of high-affinity CD8+ TEM cells in the gut mucosa.

References

  1. Nagler-Anderson, C. Nat. Rev. Immunol. 1, 59–67 (2001).

    Article  CAS  Google Scholar 

  2. Masopust, D., Vezys, V., Marzo, A.L. & Lefrancois, L. Science 291, 2413–2417 (2001).

    Article  CAS  Google Scholar 

  3. Reinhardt, R.L., Khoruts, A., Merica, R., Zell, T. & Jenkins, M.K. Nature 410, 101–105 (2001).

    Article  CAS  Google Scholar 

  4. Huang, Y. et al. Nat. Immunol. 12, 1086–1095 (2011).

    Article  CAS  Google Scholar 

  5. Olivares-Villagomez, D. & Van Kaer, L. Immunol. Lett. 134, 1–6 (2010).

    Article  CAS  Google Scholar 

  6. Leishman, A.J. et al. Science 294, 1936–1939 (2001).

    Article  CAS  Google Scholar 

  7. Liu, Y. et al. Immunity 18, 205–215 (2003).

    Article  CAS  Google Scholar 

  8. Olivares-Villagomez, D. et al. Proc. Natl. Acad. Sci. USA 105, 17931–17936 (2008).

    Article  CAS  Google Scholar 

  9. Madakamutil, L.T. et al. Science 304, 590–593 (2004).

    Article  CAS  Google Scholar 

  10. Mora, J.R. et al. J. Exp. Med. 201, 303–316 (2005).

    Article  CAS  Google Scholar 

  11. Cheroutre, H. & Lambolez, F. Immunity 28, 149–159 (2008).

    Article  CAS  Google Scholar 

  12. Williams, M.A. & Bevan, M.J. J. Immunol. 175, 2066–2069 (2005).

    Article  CAS  Google Scholar 

  13. Chandele, A. & Kaech, S.M. J. Immunol. 175, 5619–5623 (2005).

    Article  CAS  Google Scholar 

  14. Zhong, W. & Reinherz, E.L. Eur. J. Immunol. 35, 3103–3110 (2005).

    Article  CAS  Google Scholar 

  15. Mbow, M.L., De Gregorio, E., Valiante, N.M. & Rappuoli, R. Curr. Opin. Immunol. 22, 411–416 (2010).

    Article  CAS  Google Scholar 

  16. Serazin, A.C., Shackelton, L.A., Wilson, C. & Bhan, M.K. Nat. Immunol. 11, 769–773 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Cathryn Nagler.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nagler, C., Wroblewska, J. TL we meet again. Nat Immunol 12, 1027–1028 (2011). https://doi.org/10.1038/ni.2138

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.2138

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing