New experimental approaches combined with statistical models show that DNA sequence strongly influences how the genome is packaged into nucleosomes. The studies predict that genes regulated by fundamentally different mechanisms have distinct nucleosome positioning signatures encoded in their DNA.
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References
Ioshikhes, I.P., Albert, I., Zanton, S.J. & Pugh, B.F. Nat. Genet. 38, 1210–1215 (2006).
Segal, E. et al. Nature 442, 772–778 (2006).
Pabo, C.O. & Nekludova, L. J. Mol. Biol. 301, 597–624 (2000).
Luger, K., Mader, A.W., Richmond, R.K., Sargent, D.F. & Richmond, T.J. Nature 389, 251–260 (1997).
Widom, J. Q. Rev. Biophys. 34, 269–324 (2001).
Lu, Q., Wallrath, L.L. & Elgin, S.C. J. Cell. Biochem. 55, 83–92 (1994).
Ioshikhes, I., Bolshoy, A., Derenshteyn, K., Borodovsky, M. & Trifonov, E.N. J. Mol. Biol. 262, 129–139 (1996).
Yuan, G.C. et al. Science 309, 626–630 (2005).
Huisinga, K.L. & Pugh, B.F. Mol. Cell 13, 573–585 (2004).
Vignali, M., Hassan, A.H., Neely, K.E. & Workman, J.L. Mol. Cell. Biol. 20, 1899–1910 (2000).
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Ercan, S., Lieb, J. New evidence that DNA encodes its packaging. Nat Genet 38, 1104–1105 (2006). https://doi.org/10.1038/ng1006-1104
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DOI: https://doi.org/10.1038/ng1006-1104