Two new studies report mutations in FAN1 and three other genome-stability genes that tie the DNA damage response to progressive kidney failure and the dysfunction of several other organs. These findings provide clues to the underlying causes of tissue decline and may add a series of genes to the growing list of genome maintenance factors that protect against premature aging.
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Progeroid genome maintenance syndromes (PDF 29 kb)
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Lans, H., Hoeijmakers, J. Genome stability, progressive kidney failure and aging. Nat Genet 44, 836–838 (2012). https://doi.org/10.1038/ng.2363
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DOI: https://doi.org/10.1038/ng.2363
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