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Photosensitivity syndrome brings to light a new transcription-coupled DNA repair cofactor

Nature Genetics volume 44, pages 477–478 (2012)Cite this article

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Three teams have applied whole-exome and proteome methods to identify a new cofactor of human RNA polymerase II that is required for the recovery of transcription on damaged templates. The identification of this new factor raises questions about the causal relationships between molecular mechanisms of transcription regulation and excision repair and developmental and neurological disease and nonmalignant skin photosensitivity.

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Figure 1: Nuclear and mitochondrial functions of the RNA Pol II cofactors ERCC6, ERCC8, UVSSA and USP7 that regulate transcription of damaged DNA and facilitate enhanced repair of the transcribed strand.

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Author notes

  1. James E. Cleaver is at the Department of Dermatology, University of California, San Francisco, California, USA.

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  1. James E Cleaver

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  1. James E Cleaver
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Correspondence to James E Cleaver.

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Cleaver, J. Photosensitivity syndrome brings to light a new transcription-coupled DNA repair cofactor. Nat Genet 44, 477–478 (2012). https://doi.org/10.1038/ng.2255

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