Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • RESEARCH BRIEFINGS

A genetic basis for asymptomatic SARS-CoV-2 infection

A common genetic variant of the human leukocyte antigen (HLA) complex, a family of genes involved in the immune response, is associated with an absence of symptoms during SARS-CoV-2 infection. Previous exposure to cold viruses seems to confer this immunity.

This is a summary of: Augusto, D. G. et al. A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection. Nature https://doi.org/10.1038/s41586-023-06331-x (2023).

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

doi: https://doi.org/10.1038/d41586-023-02102-w

Figure 1 is published under a CC BY 4.0 licence.

References

  1. The Severe Covid-19 GWAS Group. N. Engl. J. Med. 383, 1522–1534 (2020).

    Article  PubMed  Google Scholar 

  2. Augusto, D. G. & Hollenbach, J. A. Curr. Opin. Immunol. 76, 102178 (2022).

    Article  PubMed  Google Scholar 

  3. Guthmiller, J. J. & Wilson, P. C. Science 370, 1272–1273 (2020).

    Article  PubMed  Google Scholar 

  4. Gragert, L., Madbouly, A., Freeman, J. & Maiers, M. Hum. Immunol. 74, 1313–1320 (2013).

    Article  PubMed  Google Scholar 

  5. Pairo-Castineira, E. et al. Nature 591, 92–98 (2021).

    Article  PubMed  Google Scholar 

Download references

Subjects

Latest on:

Nature Careers

Jobs

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Advanced search

Quick links