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A protein pattern regulates the positions and connections of neuronal cells

In the neocortex of the brain, excitatory neuronal cells that arise from the same progenitor cell express patterned combinations of clustered protocadherin proteins (cPCDHs). The pattern of cPCDHs expressed by a neuron regulates its spatial positioning and its connections with other neurons.

This is a summary of: Lv, X. et al. Patterned cPCDH expression regulates the fine organization of the neocortex. Nature https://doi.org/10.1038/s41586-022-05495-2 (2022).

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doi: https://doi.org/10.1038/d41586-022-03623-6

‘Expert opinion’ is published under a CC BY 4.0 licence.

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