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  • RESEARCH HIGHLIGHT

PROTAC induces HIV-1 Nef degradation

  1. Sarah Crunkhorn
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The HIV-1 accessory protein Nef plays an essential role in HIV-1 pathogenesis, enhancing viral infectivity and promoting immune escape, making it an attractive antiretroviral drug target. Although several studies have reported drug discovery efforts targeting HIV-1 Nef, these have been complicated by the fact that Nef lacks intrinsic enzymatic activity and an active site.

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Nature Reviews Drug Discovery 23, 340 (2024)

doi: https://doi.org/10.1038/d41573-024-00060-0

References

  1. Emert-Sedlak, L. A. et al. PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication. Cell Chem. Biol. https://doi.org/10.1016/j.chembiol.2024.02.004 (2024)

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